Trifluoroacetic acid → HCID 136198181, compound

HRID 454557Notes

Reaction equation

HRID 454557 reaction equation
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:38]=[CH:37][C:36]([C:39]2[CH:44]=[CH:43][N:42]=[CH:41][CH:40]=2)=[CH:35][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][CH3:34])[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[OH:8][C:9]1[CH:38]=[CH:37][C:36]([C:39]2[CH:40]=[CH:41][N:42]=[CH:43][CH:44]=2)=[CH:35][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[O:33][CH3:34])[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136198173HCID 136198173, compound

Product 1

HCID 136198181HCID 136198181, compound

Procedure

A trifluoroacetic acid (4.0 mL) solution of the obtained tert-butyl 2-(2-hydroxy-5-(pyridin-4-yl)benzamido)-4-(2-methoxyphenyl)benzoate was stirred at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, and toluene was added to the residue. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 0.027 g of 2-(2-hydroxy-5-(pyridin-4-yl)benzamido)-4-(2-methoxyphenyl)benzoic acid as a light yellow solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and toluene
  2. additionwas added to the residue
  3. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
  4. additionwas added to the obtained residue
  5. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-867f0080915e441b9051d243efb9c923
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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