Hydrochloric Acid → HCID 58508584, compound

HRID 454560Notes

Reaction equation

HRID 454560 reaction equation
[OH-].[Na+].C([O:6][C:7]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][CH3:34])=[CH:28][C:8]=1[C:9]([NH:11][C:12]1[CH:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=[CH:18][C:13]=1[C:14]([O:16]C)=[O:15])=[O:10])(=O)C.Cl>CO>[CH2:33]([O:32][C:29]1[CH:30]=[CH:31][C:7]([OH:6])=[C:8]([CH:28]=1)[C:9]([NH:11][C:12]1[CH:21]=[C:20]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:19]=[CH:18][C:13]=1[C:14]([OH:16])=[O:15])=[O:10])[CH3:34]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66990779HCID 66990779, compound

Product 1

HCID 58508584HCID 58508584, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanol (4 mL) and a 2 mol/L aqueous solution of sodium hydroxide (0.95 mL) were added to the obtained methyl 2-(2-acetoxy-5-ethoxybenzamido)-4-phenylbenzoate (0.082 g), followed by stirring at room temperature for 3 hours and 30 minutes and then heating to reflux for 30 minutes. The reaction mixture was cooled to room temperature and adjusted to a pH of 1.2 with 6 mol/L hydrochloric acid. The solid substance was collected by filtration to obtain 0.055 g of 2-(5-ethoxy-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. temperatureheating
  2. temperatureto reflux for 30 minutes
  3. temperatureThe reaction mixture was cooled to room temperature
  4. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-5863c91f49f144e38af89833c41cb2a0
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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