反应详情

To a solution mixture of the obtained tert-butyl 2-(2-(benzyloxy)-5-phenoxybenzamido)-4-phenylbenzoate (0.049 g) in methanol (1.5 mL) and ethyl acetate (1.5 mL), 10% palladium-carbon (0.025 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours. To the reaction mixture, 10% palladium-carbon (0.050 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours. Ethyl acetate was added to the reaction mixture, and the insoluble substance was removed by filtration. The solvent was evaporated under reduced pressure, and hexane was added to the obtained residue. The solid substance was collected by filtration to obtain 0.017 g of tert-butyl 2-(2-hydroxy-5-phenoxybenzamido)-4-phenylbenzoate as a white solid.

1. additionwas added
2. stirringby stirring under a hydrogen atmosphere at room temperature for 2 hours
3. customthe insoluble substance was removed by filtration
4. customThe solvent was evaporated under reduced pressure, and hexane
5. additionwas added to the obtained residue
6. filtrationThe solid substance was collected by filtration