反应详情

Under ice-cooling, trifluoroacetic acid (1.0 mL) was added to a methylene chloride (2.0 mL) solution of the obtained tert-butyl 2-(2-(methoxymethoxy)-5-((piperidin-1-yl)methyl)benzamido)-4-phenylbenzoate (0.080 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and ethyl acetate was added to the obtained residue. The solid substance was collected by filtration. Ethyl acetate (1.0 mL) and a 4.0 mol/L hydrogen chloride-dioxane solution (0.20 mL) were added to the obtained solid substance, followed by stirring at room temperature for 3 hours. The solid substance was collected from the reaction mixture by filtration to obtain 0.020 g of 2-(2-hydroxy-5-((piperidin-1-yl)methyl)benzamido)-4-phenylbenzoic acid hydrochloride as a white solid.

1. temperatureUnder ice-cooling
2. customThe solvent was evaporated under reduced pressure, and ethyl acetate
3. additionwas added to the obtained residue
4. filtrationThe solid substance was collected by filtration
5. additionEthyl acetate (1.0 mL) and a 4.0 mol/L hydrogen chloride-dioxane solution (0.20 mL) were added to the obtained solid substance
6. stirringby stirring at room temperature for 3 hours
7. filtrationThe solid substance was collected from the reaction mixture by filtration