HCID 66991612, compound → HCID 58508818, compound

HRID 454660Notes

Reaction equation

HRID 454660 reaction equation
C([O:8][C:9]1[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][N:40]2[CH2:45][CH2:44][N:43]([CH2:46][CH3:47])[CH2:42][CH2:41]2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[O:12])C1C=CC=CC=1>[C].[Pd].CO>[CH2:46]([N:43]1[CH2:42][CH2:41][N:40]([CH2:39][CH2:38][O:37][C:34]2[CH:35]=[CH:36][C:9]([OH:8])=[C:10]([CH:33]=2)[C:11]([NH:13][C:14]2[CH:26]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH:24]=[CH:23][C:15]=2[C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])=[O:12])[CH2:45][CH2:44]1)[CH3:47]

Participants

4

Reactant 1

HCID 66991612HCID 66991612, compound

Product 1

HCID 58508818HCID 58508818, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalyst2×HCID 887MethanolSolvent

Procedure

To a methanol (20 mL) solution of the obtained tert-butyl 2-(2-(benzyloxy)-5-(2-(4-ethylpiperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate, 10% palladium-carbon (1.7 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours and 30 minutes. To the reaction mixture, 10% palladium-carbon (0.70 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 3 hours. The insoluble substance was removed by filtration, and then the solvent was evaporated under reduced pressure to obtain tert-butyl 2-(5-(2-(4-ethylpiperazin-1-yl)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoate as a white solid.

Workup

  1. stirringby stirring under a hydrogen atmosphere at room temperature for 3 hours
  2. customThe insoluble substance was removed by filtration
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d3e1e668131041ddaa375d70338a6fc3
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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