HCID 66991612, compound → HCID 58508818, compound

Participants

Reaction Steps

To a methanol (20 mL) solution of the obtained tert-butyl 2-(2-(benzyloxy)-5-(2-(4-ethylpiperazin-1-yl)ethoxy)benzamido)-4-phenylbenzoate, 10% palladium-carbon (1.7 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 2 hours and 30 minutes. To the reaction mixture, 10% palladium-carbon (0.70 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 3 hours. The insoluble substance was removed by filtration, and then the solvent was evaporated under reduced pressure to obtain tert-butyl 2-(5-(2-(4-ethylpiperazin-1-yl)ethoxy)-2-hydroxybenzamido)-4-phenylbenzoate as a white solid.

Provenance & Evidence