反应详情

To a solution mixture of the obtained tert-butyl 2-(2-(benzyloxy)-5-(morpholin-4-yl)benzamido)-4-phenylbenzoate (0.060 g) in ethyl acetate (1.5 mL) and methanol (1.5 mL), 10% palladium-carbon (0.030 g) was added, followed by stirring under a hydrogen atmosphere at room temperature for 3 hours and 30 minutes. Ethyl acetate was added to the reaction mixture. The insoluble substance was removed by filtration, and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 0.036 g of tert-butyl 2-(2-hydroxy-5-(morpholin-4-yl)benzamido)-4-phenylbenzoate as a yellow solid.

1. additionwas added
2. customThe insoluble substance was removed by filtration
3. customthe solvent was evaporated under reduced pressure
4. additionDiisopropyl ether was added to the obtained residue
5. filtrationThe solid substance was collected by filtration