反应详情

Trifluoroacetic acid (3 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(morpholin-4-yl)benzamido)-4-phenylbenzoate (0.036 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and water and 2-propanol were added to the obtained residue. After adjusting the pH to 6.0 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected by filtration to obtain 0.027 g of 2-(2-hydroxy-5-(morpholin-4-yl)benzamido)-4-phenylbenzoic acid as a yellow solid.

1. customThe solvent was evaporated under reduced pressure, and water and 2-propanol
2. additionwere added to the obtained residue
3. filtrationthe solid substance was collected by filtration