Hydrochloric Acid → HCID 66990047, compound

Participants

Reaction Conditions

Reaction Steps

A 2.0 mol/L aqueous solution of sodium hydroxide (0.37 mL) was added to a 2-propanol (1.0 mL) suspension of the obtained methyl 2-(2-hydroxy-5-((1-methylpiperidin-4-yl)methoxy)benzamido)-4-phenylbenzoate (0.070 g), followed by stirring at 50° C. for 1 hour and 30 minutes. The reaction mixture was cooled to room temperature, and then water was added thereto. After adjusting the pH to 6.0 with 1 mol/L hydrochloric acid, the solid substance was collected by filtration. Ethyl acetate (2.0 mL) and a 4 mol/L hydrogen chloride dioxane solution (0.20 mL) were added to the obtained solid substance, followed by stirring at room temperature for 2 hours. The solid substance was collected from the reaction mixture by filtration to obtain 0.058 g of 2-(2-hydroxy-5-(1-methylpiperidin-4-ylmethoxy)benzamido)-4-phenylbenzoic acid hydrochloride as a light yellow solid.

Provenance & Evidence