Hydrochloric Acid → HCID 66990047, compound

HRID 454704Notes

Reaction equation

HRID 454704 reaction equation
[OH-].[Na+].CC(O)C.[OH:7][C:8]1[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[CH:29][C:9]=1[C:10]([NH:12][C:13]1[CH:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:20]=[CH:19][C:14]=1[C:15]([O:17]C)=[O:16])=[O:11].[ClH:42]>O>[ClH:42].[OH:7][C:8]1[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH:35]2[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]2)=[CH:29][C:9]=1[C:10]([NH:12][C:13]1[CH:22]=[C:21]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:20]=[CH:19][C:14]=1[C:15]([OH:17])=[O:16])=[O:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 14798Sodium HydroxideHCID 58508553HCID 58508553, compound

Product 1

HCID 66990047HCID 66990047, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A 2.0 mol/L aqueous solution of sodium hydroxide (0.37 mL) was added to a 2-propanol (1.0 mL) suspension of the obtained methyl 2-(2-hydroxy-5-((1-methylpiperidin-4-yl)methoxy)benzamido)-4-phenylbenzoate (0.070 g), followed by stirring at 50° C. for 1 hour and 30 minutes. The reaction mixture was cooled to room temperature, and then water was added thereto. After adjusting the pH to 6.0 with 1 mol/L hydrochloric acid, the solid substance was collected by filtration. Ethyl acetate (2.0 mL) and a 4 mol/L hydrogen chloride dioxane solution (0.20 mL) were added to the obtained solid substance, followed by stirring at room temperature for 2 hours. The solid substance was collected from the reaction mixture by filtration to obtain 0.058 g of 2-(2-hydroxy-5-(1-methylpiperidin-4-ylmethoxy)benzamido)-4-phenylbenzoic acid hydrochloride as a light yellow solid.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationthe solid substance was collected by filtration
  3. additionEthyl acetate (2.0 mL) and a 4 mol/L hydrogen chloride dioxane solution (0.20 mL) were added to the obtained solid substance
  4. stirringby stirring at room temperature for 2 hours
  5. filtrationThe solid substance was collected from the reaction mixture by filtration

Sources & evidence

ORD record
ord-90393c31782c4694a1fbd4e2773b362f
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

Loading…