Trifluoroacetic acid → HCID 66991403, compound

HRID 454718Notes

Reaction equation

HRID 454718 reaction equation
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:36]=[CH:35][C:34]([CH:37]2[CH2:42][CH2:41][CH2:40][NH:39][CH2:38]2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>>[OH:8][C:9]1[CH:36]=[CH:35][C:34]([CH:37]2[CH2:42][CH2:41][CH2:40][NH:39][CH2:38]2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66990440HCID 66990440, compound

Product 1

HCID 66991403HCID 66991403, compoundYield 99.9%

Procedure

Trifluoroacetic acid (2.0 mL) was added to the obtained tert-butyl 2-(2-hydroxy-5-(piperidin-3-yl)benzamido)-4-phenylbenzoate (0.10 g), followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and methanol and water were added the residue. After adjusting the pH to 6.0 with a saturated aqueous solution of sodium bicarbonate, the solid substance was collected from the reaction mixture by filtration to obtain 0.088 g of 2-(2-hydroxy-5-(piperidin-3-yl)benzamido)-4-phenylbenzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and methanol and water
  2. additionwere added the residue
  3. filtrationthe solid substance was collected from the reaction mixture by filtration

Sources & evidence

ORD record
ord-4ba267813a9747119deb59a9112dc30b
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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