Trifluoroacetic acid → HCID 58508422, compound

HRID 454730Notes

Reaction equation

HRID 454730 reaction equation
FC(F)(F)C(O)=O.[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([O:20]C(C)(C)C)=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][CH:33]=[C:34]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[CH:35]=3)=[O:29])[CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([OH:20])=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][CH:33]=[C:34]([C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)[CH:35]=3)=[O:29])[CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58508645HCID 58508645, compound

Product 1

HCID 58508422HCID 58508422, compound

Procedure

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 4-phenyl-2-(5-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and ethyl acetate was added to the obtained residue. The solid substance was collected by filtration to obtain 40 mg of 4-phenyl-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure, and ethyl acetate
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-2f96e503ac2644058ef28afcdb142893
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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