Methanol → HCID 66990173, compound

HRID 454734Notes

Reaction equation

HRID 454734 reaction equation
CO.[OH-].[Na+:4].[CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=[O:20])=[C:17]([NH:24][C:25]([C:27]3[CH:28]=[N:29][CH:30]=[C:31]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[CH:32]=3)=[O:26])[CH:16]=2)=[CH:7][N:6]=1>O1CCOCC1>[CH:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]2[CH:23]=[CH:22][C:18]([C:19]([O-:21])=[O:20])=[C:17]([NH:24][C:25]([C:27]3[CH:28]=[N:29][CH:30]=[C:31]([C:33]4[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=4)[CH:32]=3)=[O:26])[CH:16]=2)=[CH:7][N:6]=1.[Na+:4]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 58508434HCID 58508434, compound

Product 1

HCID 66990173HCID 66990173, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methanol (5 mL), dioxane (5 mL), and a 2 mol/L aqueous solution of sodium hydroxide (0.091 mL) were added to the obtained 4-(isoquinolin-4-yl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid (81 mg), and the solvent was evaporated under reduced pressure. Diisopropyl ether was added to the obtained residue, and the solid substance was collected by filtration to obtain 83 mg of sodium 4-(isoquinolin-4-yl)-2-(5-phenylpyridine-3-carboxamido)benzoate as a light yellow solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionDiisopropyl ether was added to the obtained residue
  3. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-c660ff7907054f91ab37d72d8db2da72
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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