Methanol → HCID 58508457, compound

HRID 454736Notes

Reaction equation

HRID 454736 reaction equation
CO.[OH-].[Na+:4].[C:5]1([C:11]2[CH:12]=[C:13]([C:17]([NH:19][C:20]3[CH:28]=[C:27]([N:29]4[CH:33]=[CH:32][CH:31]=[N:30]4)[CH:26]=[CH:25][C:21]=3[C:22]([OH:24])=[O:23])=[O:18])[CH:14]=[N:15][CH:16]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>O1CCOCC1>[C:5]1([C:11]2[CH:12]=[C:13]([C:17]([NH:19][C:20]3[CH:28]=[C:27]([N:29]4[CH:33]=[CH:32][CH:31]=[N:30]4)[CH:26]=[CH:25][C:21]=3[C:22]([O-:24])=[O:23])=[O:18])[CH:14]=[N:15][CH:16]=2)[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1.[Na+:4]

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 58508458HCID 58508458, compound

Product 1

HCID 58508457HCID 58508457, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methanol (2 mL), dioxane (2 mL), and a 2 mol/L aqueous solution of sodium hydroxide (0.083 mL) were added to the obtained 2-(5-phenylpyridine-3-carboxamido)-4-(1H-pyrazol-1-yl)-benzoic acid (53 mg), and the solvent was evaporated under reduced pressure. Water and acetone were added to the obtained residue, and the solid substance was collected by filtration to obtain 23 mg of sodium 2-(5-phenylpyridine-3-carboxamido)-4-(1H-pyrazol-1-yl)benzoate as a white solid.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionWater and acetone were added to the obtained residue
  3. filtrationthe solid substance was collected by filtration

Sources & evidence

ORD record
ord-7058e33137db454a8a9e31e807b61e12
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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