Sodium Hydroxide → HCID 66990723, compound

HRID 454743Notes

Reaction equation

HRID 454743 reaction equation
[OH-].[Na+:2].[CH2:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[C:14]([NH:21][C:22]([C:24]2[CH:25]=[N:26][CH:27]=[C:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:29]=2)=[O:23])[CH:13]=1)[CH3:4]>C(O)C>[CH2:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12]1[CH:20]=[CH:19][C:15]([C:16]([O-:18])=[O:17])=[C:14]([NH:21][C:22]([C:24]2[CH:25]=[N:26][CH:27]=[C:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:29]=2)=[O:23])[CH:13]=1)[CH3:4].[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66990611HCID 66990611, compound

Product 1

HCID 66990723HCID 66990723, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (18 mL) and a 1.0 mol/L aqueous solution of sodium hydroxide (1.3 mL) were sequentially added to the obtained 4-(2-(ethylamino)phenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid (0.60 g), followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and a 10% aqueous solution of ethanol was added to the obtained residue. The solid substance was collected by filtration to obtain 0.57 g of sodium 4-(2-(ethylamino)phenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate as a light yellow solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additiona 10% aqueous solution of ethanol was added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-86868d8ea5604d95aaf9b22af1564c3c
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

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