反应详情

Trifluoroacetic acid (4.0 mL) was added to the obtained tert-butyl 4-(2-methoxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate (61 mg), followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration, and dioxane (3.0 mL), water, and a 2 mol/L aqueous solution of sodium hydroxide (0.080 mL) were added to the obtained residue. After adjusting the pH to 7.6 with 1 mol/L hydrochloric acid, the solid substance was collected by filtration to obtain 32 mg of 4-(2-methoxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a white solid.

1. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
2. additionwas added to the obtained residue
3. filtrationThe solid substance was collected by filtration, and dioxane (3.0 mL), water
4. additiona 2 mol/L aqueous solution of sodium hydroxide (0.080 mL) were added to the obtained residue
5. filtrationthe solid substance was collected by filtration