Sodium Hydroxide → Sodium 4-(2-fluorophenyl)-2-(5-phenylpyridine-3-carboxamido)-benzoate

HRID 454760Notes

Reaction equation

HRID 454760 reaction equation
[OH-].[Na+:2].[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:19][C:20]([C:22]2[CH:23]=[N:24][CH:25]=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH:27]=2)=[O:21])[CH:11]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([O-:16])=[O:15])=[C:12]([NH:19][C:20]([C:22]2[CH:23]=[N:24][CH:25]=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH:27]=2)=[O:21])[CH:11]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 585085154-(2-Fluorophenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid

Product 1

HCID 58508514Sodium 4-(2-fluorophenyl)-2-(5-phenylpyridine-3-carboxamido)-benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethanol (1.5 mL) and a 1 mol/L aqueous solution of sodium hydroxide (0.087 mL) were sequentially added to the obtained 4-(2-fluorophenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid (36 mg), followed by stirring at room temperature for 3 hours. The solid substance was collected by filtration to obtain 22 mg of sodium 4-(2-fluorophenyl)-2-(5-phenylpyridine-3-carboxamido)-benzoate as a white solid.

Workup

  1. filtrationThe solid substance was collected by filtration

Sources & evidence

ORD record
ord-9f892ce130fd41d28e01b5164eb52546
Source dataset
uspto-grants-2013_07
Patent number
US08492582B2

Reaction notes

Loading…