HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monomethylamine methanol → 2-[2-(N-monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monomethylamine methanol | HCID 57454252 | — |
| Reactant | 2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 86646557 | — |
| Product | 2-[2-(N-monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene | HCID 46947728 | 81% |
Reaction Steps
2-[2-(N-Monomethylamino)pyrimidine-4-yl]-6-(3-fluoropropoxy)benzothiophene (1-38, 56 mg, 81%) was prepared in the same manner as in Example 35 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 2.0 M methylamine methanol solution (NH2Me in MeOH, 0.17 mL, 0.34 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497260B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-5a8dd2395eee48f8be36faf4892656d1 |
| Source note | uspto-grants-2013_07 |