1-[N-[4-(3-carbamoyl-4-hydroxyphenoxy)butyl]benzylamino]-3-[4-(2-methoxyethoxy)-phenoxy]propan-2-ol → HCID 13754392, compound

HRID 4549Notes

Reaction equation

HRID 4549 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:36]=[CH:37][C:38]=1[OH:39])[O:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12](CC1C=CC=CC=1)[CH2:13][CH:14]([OH:28])[CH2:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][O:26][CH3:27])=[CH:19][CH:18]=1)(=[O:3])[NH2:2]>CO>[C:1]([C:4]1[CH:5]=[C:6]([CH:36]=[CH:37][C:38]=1[OH:39])[O:7][CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:28])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH2:24][CH2:25][O:26][CH3:27])=[CH:21][CH:22]=1)(=[O:3])[NH2:2]

Participants

3

Reactant 1

HCID 540252471-[N-[4-(3-carbamoyl-4-hydroxyphenoxy)butyl]benzylamino]-3-[4-(2-methoxyethoxy)-phenoxy]propan-2-ol

Product 1

HCID 13754392HCID 13754392, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 25 g of crude 1-[N-[4-(3-carbamoyl-4-hydroxyphenoxy)butyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]propan-2-ol in 250 ml of methanol is hydrogenated and worked up analogously to Example 4. The resulting crystalline crude product is recrystallised from isopropanol and yields 1-[4-(3-carbamoyl-4-hydroxyphenoxy)butylamino]-3-[4-(2-methoxyethoxy)phenoxy]propan-2-ol having a melting point of 122°-124°.

Workup

  1. customThe resulting crystalline crude product is recrystallised from isopropanol

Sources & evidence

ORD record
ord-2ae538c41730482c9160ea66680d7309
Source dataset
uspto-grants-1988_02
Patent number
US04727067

Reaction notes

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