Hydrochloric Acid → HCID 178524923, compound

HRID 455014Notes

Reaction equation

HRID 455014 reaction equation
C([O:3][C:4]([C:6]1[NH:7][N:8]=[C:9]2[C:14]=1[CH2:13][CH2:12][N:11]([C:15]([C:17]1[CH:25]=[CH:24][C:20]3[NH:21][N:22]=[N:23][C:19]=3[CH:18]=1)=[O:16])[CH2:10]2)=[O:5])C.[OH-].[Na+].C(O)C.Cl>O>[NH:21]1[C:20]2[CH:24]=[CH:25][C:17]([C:15]([N:11]3[CH2:12][CH2:13][C:14]4=[C:6]([C:4]([OH:5])=[O:3])[NH:7][N:8]=[C:9]4[CH2:10]3)=[O:16])=[CH:18][C:19]=2[N:23]=[N:22]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium Hydroxide2×HCID 178470412HCID 178470412, compound

Product 1

HCID 178524923HCID 178524923, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Starting material 40 (2.6 g, 6.4 mmol) was mixed with 2 N NaOH (15 ml) and ethanol (15 ml) and stirred at ambient temperature. Additional 15 ml 2 N NaOH were added. After the reaction was completed, the mixture was reduced to dryness, the solid was dissolved in water, adjusted to pH 2 with 2N HCl and the resulting precipitate was filtered and dried. Thus the desired product 41 (1.4 g, 4.4 mmol, 57%) could be isolated as solid.

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried

Sources & evidence

ORD record
ord-7897724ba85540d5960b29558d5175ec
Source dataset
uspto-grants-2013_07
Patent number
US08497283B2

Reaction notes

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