1H-1,2,4-Triazole → 3-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-chlorophenyl)imidazo[1,2-b]pyridazine

HRID 455024Notes

Reaction equation

HRID 455024 reaction equation
[N:1]1(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)C=CN=C1.Cl.Cl[CH2:26][C:27]1[N:31]2C=[CH:33][CH:34]=[CH:35][C:30]2=[N:29][C:28]=1[C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=1.[NH:43]1[CH:47]=[N:46][CH:45]=[N:44]1>>[N:43]1([CH2:26][C:27]2[N:31]3[N:1]=[CH:33][CH:34]=[CH:35][C:30]3=[N:29][C:28]=2[C:36]2[CH:37]=[CH:38][C:39]([Cl:42])=[CH:40][CH:41]=2)[CH:47]=[N:46][CH:45]=[N:44]1

Participants

4

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 583370713-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridineHCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 445394343-((1H-1,2,4-triazol-1-yl)methyl)-2-(4-chlorophenyl)imidazo[1,2-b]pyridazine

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 1H-1,2,4-triazole. 1H-NMR (CDCl3, 400 MHz, δ) 8.74 (s, 1H) 8.07 (d, J=8.5 Hz, 2H), 8.07 (d, J=8.5 Hz, 2H), 8.01 (dd, J=1.3, 9.2 Hz, 1H), 7.95 (s, 1H), 7.51 (m, 2H), 7.17 (dd, J=4.5, 9.2 Hz, 1H), 5.85 (s, 2H) ppm; [M+H]+ 311

Sources & evidence

ORD record
ord-b92c5e08de7e4b418fb4ac519b38ec1c
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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