Methyl indoline-2-carboxylate → Methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)indoline-2-carboxylate
반응식
N1(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)C=CN=C1.Cl.Cl[CH2:26][C:27]1[N:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]2=[N:29][C:28]=1[C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=1.[NH:43]1[C:51]2[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=2)[CH2:45][CH:44]1[C:52]([O:54][CH3:55])=[O:53]>>[Cl:42][C:39]1[CH:40]=[CH:41][C:36]([C:28]2[N:29]=[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]3[C:27]=2[CH2:26][N:43]2[C:51]3[C:46](=[CH:47][CH:48]=[CH:49][CH:50]=3)[CH2:45][CH:44]2[C:52]([O:54][CH3:55])=[O:53])=[CH:37][CH:38]=1참가 물질
4
반응물 3
생성물 1
실험 절차
The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and methyl indoline-2-carboxylate. M/e+ 418 for C24H21ClN3O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.33 (d, J=6.9 Hz, 1H), 7.69 (d, J=8.4 Hz, 2H), 7.64 (d, J=9.1 Hz, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.25 (t, J=6.9 Hz, 1H), 7.09 (t, J=7.7 Hz, 1H), 7.04 (d, J=6.9 Hz, 1H), 6.83 (t, J=6.6 Hz, 1H), 6.75 (t, J=7.7 Hz, 1H), 6.60 (d, J=7.7 Hz, 1H), 4.90 (d, J=14.7 Hz, 1H), 4.62 (d, J=14.7 Hz, 1H), 3.85 (t, J=8.4 Hz, 1H), 3.26 (m, 1H), 3.23 (s, 3H), 2.96 (dd, J=15.7, 8.0 Hz, 1H) ppm.
출처 및 근거
- ORD 기록
- ord-e8dd510a07064508b962f0079b038718
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08497278B2
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