Methyl indoline-2-carboxylate → Methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)indoline-2-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Methyl indoline-2-carboxylate	HCID 2794655	—
반응물	3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine	HCID 58337071	—
반응물	3-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride	HCID 67028719	—
생성물	Methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)indoline-2-carboxylate	HCID 67028780	—

반응 단계

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and methyl indoline-2-carboxylate. M/e+ 418 for C24H21ClN3O2 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.33 (d, J=6.9 Hz, 1H), 7.69 (d, J=8.4 Hz, 2H), 7.64 (d, J=9.1 Hz, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.25 (t, J=6.9 Hz, 1H), 7.09 (t, J=7.7 Hz, 1H), 7.04 (d, J=6.9 Hz, 1H), 6.83 (t, J=6.6 Hz, 1H), 6.75 (t, J=7.7 Hz, 1H), 6.60 (d, J=7.7 Hz, 1H), 4.90 (d, J=14.7 Hz, 1H), 4.62 (d, J=14.7 Hz, 1H), 3.85 (t, J=8.4 Hz, 1H), 3.26 (m, 1H), 3.23 (s, 3H), 2.96 (dd, J=15.7, 8.0 Hz, 1H) ppm.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08497278B2
출처 데이터셋	uspto-grants-2013_07
ORD ID	ord-e8dd510a07064508b962f0079b038718
출처 메모	uspto-grants-2013_07