3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine → 3-((1H-tetrazol-1-yl)methyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

HRID 455031Notes

Reaction equation

HRID 455031 reaction equation
N1(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)C=CN=C1.Cl.Cl[CH2:26][C:27]1[N:31]2[CH:32]=[CH:33][CH:34]=[CH:35][C:30]2=[N:29][C:28]=1[C:36]1[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=1.[NH:43]1[CH:47]=[N:46][N:45]=[N:44]1>>[N:43]1([CH2:26][C:27]2[N:31]3[CH:32]=[CH:33][CH:34]=[CH:35][C:30]3=[N:29][C:28]=2[C:36]2[CH:41]=[CH:40][C:39]([Cl:42])=[CH:38][CH:37]=2)[CH:47]=[N:46][N:45]=[N:44]1

Participants

4

Reactant 3

HCID 583370713-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridineHCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochlorideHCID 178418441HCID 178418441, compound

Product 1

HCID 670286943-((1H-tetrazol-1-yl)methyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 1 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 1H-tetrazole. M/e+ 311 for C15H12ClN6 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.45 (s, 1H), 8.12 (d, J=6.9 Hz, 1H), 7.73 (d, J=9.1 Hz, 1H), 7.64 (d, J=8.4 Hz, 2H), 7.50 (d, J=8.4 Hz, 2H), 7.37 (td, J=6.9, 1.1 Hz, 1H), 6.97 (m, 1H), 6.03 (s, 2H) ppm.

Sources & evidence

ORD record
ord-b9705faedb7b4edabac5c7e424b74e1c
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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