HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → 3-((1H-pyrazol-1-yl)methyl)-6,8-dichloro-2-p-tolylimidazo[1,2-a]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 3-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine | HCID 58337071 | — |
| Reactant | 6,8-Dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride | HCID 67028900 | — |
| Product | 3-((1H-pyrazol-1-yl)methyl)-6,8-dichloro-2-p-tolylimidazo[1,2-a]pyridine | HCID 67028959 | — |
Reaction Steps
The title compound was prepared according to Method A and the experimentals described for compound 1 from 6,8-dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 1H-pyrazole. m/e+ 357 for C18H15Cl2N4 [M+H]+; 1H-NMR (300 MHz, CDCl3) δ 8.28 (d, J=2.1 Hz, 1H), 7.67 (d, J=7.8 Hz, 2H), 7.60 (d, J=1.5 Hz, 1H), 7.35 (d, J=7.8 Hz, 2H), 7.30 (m, 2H), 6.31 (t, J=2.7 Hz, 1H), 5.71 (s, 2H), 2.44 (s, 3H) ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497278B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-cd49af6a9d83428498ddaf5add035cb4 |
| Source note | uspto-grants-2013_07 |