Pyrazole → 3-((1H-pyrazol-1-yl)methyl)-6,8-dichloro-2-p-tolylimidazo[1,2-a]pyridine

HRID 455034Notes

Reaction equation

HRID 455034 reaction equation
[N:1]1([CH2:6][C:7]2N3C=C(C)C=CC3=[N:9][C:8]=2C2C=CC(C)=CC=2)C=CN=C1.Cl.[Cl:25][C:26]1[CH:27]=[C:28]([Cl:44])[C:29]2[N:30]([C:32]([CH2:42]Cl)=[C:33]([C:35]3[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][CH:36]=3)[N:34]=2)[CH:31]=1.N1C=CC=N1>>[N:9]1([CH2:42][C:32]2[N:30]3[CH:31]=[C:26]([Cl:25])[CH:27]=[C:28]([Cl:44])[C:29]3=[N:34][C:33]=2[C:35]2[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][CH:36]=2)[CH:8]=[CH:7][CH:6]=[N:1]1

Participants

4

Reactant 3

HCID 1048PyrazoleHCID 583370713-((1H-imidazol-1-yl)methyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridineHCID 670289006,8-Dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 670289593-((1H-pyrazol-1-yl)methyl)-6,8-dichloro-2-p-tolylimidazo[1,2-a]pyridine

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 1 from 6,8-dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 1H-pyrazole. m/e+ 357 for C18H15Cl2N4 [M+H]+; 1H-NMR (300 MHz, CDCl3) δ 8.28 (d, J=2.1 Hz, 1H), 7.67 (d, J=7.8 Hz, 2H), 7.60 (d, J=1.5 Hz, 1H), 7.35 (d, J=7.8 Hz, 2H), 7.30 (m, 2H), 6.31 (t, J=2.7 Hz, 1H), 5.71 (s, 2H), 2.44 (s, 3H) ppm.

Sources & evidence

ORD record
ord-cd49af6a9d83428498ddaf5add035cb4
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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