Dimethylamine → HCID 67029007, compound

HRID 455042Notes

Reaction equation

HRID 455042 reaction equation
[CH3:1][NH:2][C:3](C1N(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)N=CN=1)=O.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[N:36]=[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]3[C:43]=2[CH2:44][N:45]2[C:49]([C:50](OC)=[O:51])=[N:48][CH:47]=[N:46]2)=[CH:31][CH:30]=1.CNC>>[Cl:28][C:29]1[CH:30]=[CH:31][C:32]([C:35]2[N:36]=[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]3[C:43]=2[CH2:44][N:45]2[C:49]([C:50]([N:2]([CH3:3])[CH3:1])=[O:51])=[N:48][CH:47]=[N:46]2)=[CH:33][CH:34]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 670274852-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamideHCID 67028732HCID 67028732, compound

Product 1

HCID 67029007HCID 67029007, compound

Procedure

The title compound was prepared according to the procedure described for compound 68 from methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxylate and dimethylamine. 1H-NMR (400 MHz, CDCl3, δ) 8.21 (d, J=6.9 Hz, 1H), 7.97 (s, 1H), 7.71 (d, J=9.2 Hz, 1H), 7.68 (d, J=8.5 Hz, 2H), 7.49 (d, J=8.4 Hz, 1H), 7.34 (m, 1H), 6.94 (m, 1H), 5.80 (s, 2H), 3.21 (s, 3H), 3.13 (s, 3H) ppm; m/e 241, 243.

Sources & evidence

ORD record
ord-d16f7ba6a50c49d9b3c81a244d120b4d
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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