Dimethylamine → 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide

HRID 455043Notes

Reaction equation

HRID 455043 reaction equation
[CH3:1][NH:2][C:3](C1N(CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)N=CN=1)=O.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[N:36]=[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]3[C:43]=2[CH2:44][N:45]2[CH:49]=[N:48][C:47]([C:50](OC)=[O:51])=[N:46]2)=[CH:31][CH:30]=1.CNC>>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([C:35]2[N:36]=[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][N:38]3[C:43]=2[CH2:44][N:45]2[CH:49]=[N:48][C:47]([C:50]([N:2]([CH3:3])[CH3:1])=[O:51])=[N:46]2)=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 670274852-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamideHCID 67028970methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-3-carboxylate

Product 1

HCID 670290351-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide

Procedure

The title compound was prepared according to the procedure described for compound 68 from methyl 1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-3-carboxylate and dimethylamine. 1H-NMR (400 MHz, CDCl3, δ) 8.65 (d, J=6.9 Hz, 1H), 7.88 (s, 1H), 7.85 (d, J=8.5 Hz, 2H), 7.66 (d, J=9.1 Hz, 1H), 7.45 (d, J=8.5 Hz, 2H), 7.28 (m, 1H), 6.89 (m, 1H), 6.04 (s, 2H), 3.15 (s, 3H), 3.06 (s, 3H) ppm; m/e 381, 383.

Sources & evidence

ORD record
ord-0200a4dccb5e4ee58e9b6c6bc10c50f8
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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