Hydrazine hydrate (1:1) → 1-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-5-carbohydrazide

HRID 455049Notes

Reaction equation

HRID 455049 reaction equation
CNC(C1[N:6](CC2N3C=C(C)C=CC3=NC=2C2C=CC(C)=CC=2)[N:7]=CN=1)=O.[F:28][C:29]1[CH:30]=[CH:31][C:32]2[N:33]([C:35]([CH2:45][N:46]3[C:50]([C:51](OC)=[O:52])=[N:49][CH:48]=[N:47]3)=[C:36]([C:38]3[CH:43]=[CH:42][C:41]([F:44])=[CH:40][CH:39]=3)[N:37]=2)[CH:34]=1.O.NN>>[F:28][C:29]1[CH:30]=[CH:31][C:32]2[N:33]([C:35]([CH2:45][N:46]3[C:50]([C:51]([NH:6][NH2:7])=[O:52])=[N:49][CH:48]=[N:47]3)=[C:36]([C:38]3[CH:39]=[CH:40][C:41]([F:44])=[CH:42][CH:43]=3)[N:37]=2)[CH:34]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 670274852-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamideHCID 67028848Methyl 1-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxylate

Product 1

HCID 670287931-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-5-carbohydrazide

Procedure

The title compound was prepared according to the procedure described for compound 68 from methyl 1-((6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-1,2,4-triazole-5-carboxylate and hydrazine hydrate. m/e+ 370 for C17H14F2N7O (M+H)+.

Sources & evidence

ORD record
ord-a082c61e07ed456499bba1b7b1e70ba9
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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