反应详情

To a solution of bis-(4-chloro-phenyl)-acetaldehyde (3.74 mmol) in methanol under a nitrogen atmosphere, N—BOC-piperazine (1.05 g, 5.61 mmol) was added, the reaction mixture was stirred for 1 hour before addition of sodium cyanoborohydride (0.28 g, 4.49 mmol). The reaction mixture was stirred for 18 hours, water added (3 ml) and the solvent removed under reduced pressure. The residue was partitioned between dichloromethane and water, the organic layer was separated, dried (MgSO4), filtered and concentrated. Purified over flash silica chromatography eluting with ethyl acetate/petroleum ether (3:7) to yield the title compound (0.18 g, 11% yield for steps 30A and 30B combined). LC/MS: (PS-A2) Rt 2.66 [M-BOC+H]+ 335.02.

1. customthe solvent removed under reduced pressure
2. customThe residue was partitioned between dichloromethane and water
3. customthe organic layer was separated
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. concentrationconcentrated
7. customPurified over flash silica chromatography
8. washeluting with ethyl acetate/petroleum ether (3:7)