Methylamine → 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-N-methyl-1H-imidazole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Methylamine	HCID 6329	—
Reactant	2-(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-2H-[1,2,4]triazole-3-carboxylic acid methylamide	HCID 67027485	—
Reactant	methyl 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-imidazole-2-carboxylate	HCID 67028990	—
Product	1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-N-methyl-1H-imidazole-2-carboxamide	HCID 44539436	—

Reaction Steps

The title compound was prepared according to the procedure described for compound 68 from methyl 1-((2-(4-chlorophenyl)imidazo[1,2-b]pyridazin-3-yl)methyl)-1H-imidazole-2-carboxylate and methylamine 1H-NMR (CDCl3, 400 MHz, δ) 8.54 (d, J=4.4 Hz, 1H), 8.09 (d, J=9.3 Hz, 1H), 7.87 (s, 1H), 7.64 (d, J=8.0 Hz, 2H), 7.51 (s, 1H), 7.47 (d, J=7.9 Hz, 2H), 7.37 (dd, J=4.5, 9.2 Hz, 1H), 6.93 (s, 1H), 6.90 (s, 1H), 6.31 (s, 2H), 2.91 (s, 3H) ppm; m/e 367 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08497278B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-ea7849ae69044335b861dd8dd2f451cc
Source note	uspto-grants-2013_07