HCID 67028888, compound → 1-((2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridin-3-yl)methyl)pyridin-2(1H)-one

HRID 455064Notes

Reaction equation

HRID 455064 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([F:13])[CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1.[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[OH:27]>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][C:10]([F:13])=[CH:9][N:8]3[C:4]=2[CH2:3][N:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]2=[O:27])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 67028888HCID 67028888, compoundHCID 178516071HCID 178516071, compound

Product 1

HCID 670291251-((2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridin-3-yl)methyl)pyridin-2(1H)-one

Procedure

The title compound was prepared according to Method B and the experimentals described for compound 91 from 3-(chloromethyl)-2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridine hydrochloride and pyridin-2-ol. 1H-NMR (CDCl3, 400 MHz, δ) 8.45 (dd, J=2.4, 4.0 Hz, 1H), 7.65 (d, J=8.4 Hz, 2H), 7.58 (dd, J=5.1, 9.8 Hz, 1H), 7.46 (d, J=8.4 Hz, 1H), 7.24 (m, 1H), 7.16 (m, 1H), 6.76 (dd, J=1.9, 6.9 Hz, 1H), 6.59 (d, J=9.1 Hz, 1H), 6.00 (m, 1H), 5.62 (s, 2H) ppm; me/354 (M+H)+

Sources & evidence

ORD record
ord-38e44377a4c44c31b0e34589a7de3e86
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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