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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 455064Generated: October 30, 2026

HCID 67028888, compound → 1-((2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridin-3-yl)methyl)pyridin-2(1H)-one

https://huagongshe.com/reaction/455064

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 67028888HCID 67028888—
ReactantHCID 178516071HCID 178516071—
Product1-((2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridin-3-yl)methyl)pyridin-2(1H)-oneHCID 67029125—

Reaction Steps

The title compound was prepared according to Method B and the experimentals described for compound 91 from 3-(chloromethyl)-2-(4-chlorophenyl)-6-fluoroimidazo[1,2-a]pyridine hydrochloride and pyridin-2-ol. 1H-NMR (CDCl3, 400 MHz, δ) 8.45 (dd, J=2.4, 4.0 Hz, 1H), 7.65 (d, J=8.4 Hz, 2H), 7.58 (dd, J=5.1, 9.8 Hz, 1H), 7.46 (d, J=8.4 Hz, 1H), 7.24 (m, 1H), 7.16 (m, 1H), 6.76 (dd, J=1.9, 6.9 Hz, 1H), 6.59 (d, J=9.1 Hz, 1H), 6.00 (m, 1H), 5.62 (s, 2H) ppm; me/354 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08497278B2
Source datasetuspto-grants-2013_07
ORD IDord-38e44377a4c44c31b0e34589a7de3e86
Source noteuspto-grants-2013_07