Dimethylamine → HCID 67028507, compound

HRID 455076Notes

Reaction equation

HRID 455076 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([NH:24][CH2:25]C)=[N:20][C:19]2=[O:27])=[CH:4][CH:3]=1.Cl[C:29]1C=CN(CC2N3C=CC=CC3=NC=2C2C=CC(Cl)=CC=2)C(=O)N=1.CNC>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([N:24]([CH3:29])[CH3:25])=[N:20][C:19]2=[O:27])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 58337018HCID 58337018, compoundHCID 67028967HCID 67028967, compound

Product 1

HCID 67028507HCID 67028507, compound

Procedure

The title compound was prepared according to the experimental for compound 132 from 4-chloro-1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2(1H)-one and dimethylamine. M/e+ 380 for C20H19ClN5O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.44 (d, J=6.9 Hz, 1H), 7.67 (d, J=8.4 Hz, 2H), 7.63 (d, J=8.8 Hz, 1H), 7.47 (d, J=8.4 Hz, 2H), 7.28 (d, J=6.9 Hz, 1H), 6.86 (t, J=6.6 Hz, 1H), 6.75 (d, J=7.7 Hz, 1H), 5.63 (d, J=7.7 Hz, 1H), 5.56 (s, 2H), 3.18 (s, 3H), 2.96 (s, 3H) ppm.

Sources & evidence

ORD record
ord-e12396d8643940278023f179e9c78dc6
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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