1H-1,2,4-Triazole → HCID 67028735, compound

HRID 455079Notes

Reaction equation

HRID 455079 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([NH:24][CH2:25]C)=[N:20][C:19]2=[O:27])=[CH:4][CH:3]=1.ClC1C=C[N:32](CC2N3C=CC=CC3=NC=2C2C=CC(Cl)=CC=2)[C:31](=O)[N:30]=1.N1C=NC=N1>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][N:11]3[C:16]=2[CH2:17][N:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH:25]=[N:32][CH:31]=[N:30]3)=[N:20][C:19]2=[O:27])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 58337018HCID 58337018, compoundHCID 67028967HCID 67028967, compound

Product 1

HCID 67028735HCID 67028735, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to the experimental for compound 132 from 4-chloro-1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2(1H)-one and 1H-1,2,4-triazole in DMF. M/e+ 404 for C20H15ClN7O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 9.24 (d, J=1.8 Hz, 1H), 8.33 (d, J=6.6 Hz, 1H), 8.18 (d, J=1.8 Hz, 2H), 8.06 (d, J=1.8 Hz, 1H), 7.67 (m, 1H), 7.66 (dd, J=8.4, 1.8 Hz, 1H), 7.49 (dd, J=8.4, 1.8 Hz, 2H), 7.34 (m, 1H), 6.95 (t, J=6.6 Hz, 1H), 6.90 (dd, J=7.3, 1.8 Hz, 1H), 5.27 (s, 2H) ppm.

Sources & evidence

ORD record
ord-5554a029a23c46dbb04991d3edbccadf
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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