2-Amino-4-methylpyrimidine → HCID 67028728, compound

HRID 455083Notes

Reaction equation

HRID 455083 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[CH3:20][C:21]1[CH:26]=[CH:25][N:24]=[C:23]([NH2:27])[N:22]=1>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]3[C:4]=2[CH2:3][NH:27][C:23]2[N:22]=[C:21]([CH3:20])[CH:26]=[CH:25][N:24]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 79392-Amino-4-methylpyrimidineHCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 67028728HCID 67028728, compound

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4-methylpyrimidin-2-amine. m/e+ 350 for C19H17ClN5[M+H]+; 1H-NMR (400 MHz, CDCl3) δ 8.18 (d, J=6.9 Hz, 1H), 7.95 (s, 1H), 7.73 (d, J=8.4 Hz, 2H), 7.62 (d, J=8.8 Hz, 1H), 7.40 (d, J=8.4 Hz, 2H), 7.20 (m, 1H), 6.76 (dt, J=1.1, 6.9 Hz, 1H), 6.42 (d, J=5.1 Hz, 1H), 5.95 (s, 1H), 5.03 (d, J=5.1 Hz, 2H) 2.28 (s, 3H) ppm.

Sources & evidence

ORD record
ord-9d74f42644ae4864a4ae2fcdee77cf30
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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