2-Amino-4-chloro-6-methylpyrimidine → HCID 86655119, compound

HRID 455084Notes

Reaction equation

HRID 455084 reaction equation
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[Cl:20][C:21]1[CH:26]=[C:25]([CH3:27])[N:24]=[C:23]([NH2:28])[N:22]=1>>[Cl:20][C:21]1[CH:26]=[C:25]([CH3:27])[N:24]=[C:23]([NH:28][CH2:3][C:4]2[N:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]3=[N:6][C:5]=2[C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[N:22]=1

Participants

3

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 86655119HCID 86655119, compound

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4-chloro-6-methylpyrimidin-2-amine. M/e+, 384.1, 386 for C19H15C12N5. 1H-NMR (400 MHz, CDCl3, δ) 8.25 (m, 1H), 7.74 (d, J=6.598 Hz, 2H), 7.63 (m, 1H), 7.42 (d, J=6.599 Hz, 2H), 7.24 (m, 1H), 6.84 (m, 1H), 6.55 (s, 1H), 5.41 (s, NH), 5.05 (d, J=5.13 Hz, 2H, D, CH2), 2.318 (s, 3H, D, CH3) ppm.

Sources & evidence

ORD record
ord-faf2edd54b08465d9a045c002bc9958f
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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