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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 455084Generated: October 30, 2026

2-Amino-4-chloro-6-methylpyrimidine → HCID 86655119, compound

https://huagongshe.com/reaction/455084

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-4-chloro-6-methylpyrimidineHCID 21810—
Reactant3-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochlorideHCID 67028719—
ProductHCID 86655119HCID 86655119—

Reaction Steps

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 4-chloro-6-methylpyrimidin-2-amine. M/e+, 384.1, 386 for C19H15C12N5. 1H-NMR (400 MHz, CDCl3, δ) 8.25 (m, 1H), 7.74 (d, J=6.598 Hz, 2H), 7.63 (m, 1H), 7.42 (d, J=6.599 Hz, 2H), 7.24 (m, 1H), 6.84 (m, 1H), 6.55 (s, 1H), 5.41 (s, NH), 5.05 (d, J=5.13 Hz, 2H, D, CH2), 2.318 (s, 3H, D, CH3) ppm.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08497278B2
Source datasetuspto-grants-2013_07
ORD IDord-faf2edd54b08465d9a045c002bc9958f
Source noteuspto-grants-2013_07