2-Amino-4-chloro-6-methylpyrimidine → HCID 86655121, compound

HRID 455086Notes

Reaction equation

HRID 455086 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([CH2:20]Cl)=[C:10]([C:12]3[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1.[Cl:22][C:23]1[CH:28]=[C:27]([CH3:29])[N:26]=[C:25]([NH2:30])[N:24]=1>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([CH2:20][NH:30][C:25]3[N:24]=[C:23]([Cl:22])[CH:28]=[C:27]([CH3:29])[N:26]=3)=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([C:16]#[N:17])=[CH:18][CH:19]=3)[N:11]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 67028972HCID 67028972, compound

Product 1

HCID 86655121HCID 86655121, compound

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 4-(6-chloro-3-(chloromethyl)imidazo[1,2-a]pyridin-2-yl)benzonitrile hydrochloride and 4-chloro-6-methylpyrimidin-2-amine. m/e+ 409.0, 411.0 for C20H14Cl2N6; H-NMR (400 MHz, CDCl3) 8.80 (s, 1H), 7.953 (d, J=8.277 Hz, 2H), 7.750 (d, J=8.093 Hz, 2H), 7.593 (d, J=9.533 Hz, 1H), 7.234 (d, J=9.551 Hz, 1H), 6.545 (s, 1H), 5.257 (s, NH), 5.03 (d, J=5.498 Hz, 2H, D, CH2), 2.311 (s, 6H, D, 2CH3) ppm.

Sources & evidence

ORD record
ord-49c6f4bdb6344fe2b943161a3d416a04
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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