2-Amino-4,6-difluoropyrimidine → N-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)-4,6-difluoropyrimidin-2-amine

HRID 455093Notes

Reaction equation

HRID 455093 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([CH2:18]Cl)=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1.[F:20][C:21]1[CH:26]=[C:25]([F:27])[N:24]=[C:23]([NH2:28])[N:22]=1>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([CH2:18][NH:28][C:23]3[N:24]=[C:25]([F:27])[CH:26]=[C:21]([F:20])[N:22]=3)=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 12014802-Amino-4,6-difluoropyrimidineHCID 670287296-Chloro-3-(chloromethyl)-2-phenylimidazo[1,2-a]pyridine hydrochloride

Product 1

HCID 67028695N-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)-4,6-difluoropyrimidin-2-amineYield 43%

Procedure

The title compound was prepared according to Method A and the experimentals described for compound 139 from 6-chloro-3-(chloromethyl)-2-phenylimidazo[1,2-a]pyridine hydrochloride and 4,6-difluoropyrimidin-2-amine. ((0.26 g, 43% yield), M/e+ 372.2 for C18H12ClF2N5 (M+H)+.

Sources & evidence

ORD record
ord-e31a4547f64a4654a121251ee30d347b
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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