Prolinol, (R)- → (R)-(1-(2-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)pyrrolidin-2-yl)methanol

HRID 455109Notes

Reaction equation

HRID 455109 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:17][NH:18][C:19]3[N:24]=[C:23]([N:25]4[CH2:30][CH2:29]C(C)(O)CC4)[CH:22]=[CH:21][N:20]=3)=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.ClC1C=CN=C(NCC2N3C=C(Cl)C=CC3=NC=2C2C=CC=CC=2)N=1.N1CC[CH2:60][C@@H:59]1[CH2:63][OH:64]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:17][NH:18][C:19]3[N:24]=[C:23]([N:25]4[CH2:30][CH2:29][CH2:60][C@@H:59]4[CH2:63][OH:64])[CH:22]=[CH:21][N:20]=3)=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 2724541Prolinol, (R)-HCID 670290991-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-olHCID 866551254-chloro-N-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine

Product 1

HCID 67028784(R)-(1-(2-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)pyrrolidin-2-yl)methanol

Procedure

The title compound was prepared in the same fashion as that described for compound 187 from 4-chloro-N-((6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine and (R)-pyrrolidin-2-ylmethanol. m/e 435 (M+H)+.

Sources & evidence

ORD record
ord-8e6420642efd4fafb51f69ab3d7608ba
Source dataset
uspto-grants-2013_07
Patent number
US08497278B2

Reaction notes

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