HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(Tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Tert-butyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate | HCID 49761014 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 1-(Tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid | HCID 23291131 | — |
Reaction Steps
To a solution of piperidine-1,3,5-tricarboxylic acid 1-tert-butyl ester 3,5-dimethyl ester (6.8 g, 22.5 mmol) in MeOH/water (4:1, 120 mL) is added K2CO3 (9.4 g, 68 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08497286B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-fc3147cd07f54baf9fda49483221cbcc |
| Source note | uspto-grants-2013_07 |