Potassium Carbonate → 1-(Tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid

HRID 455249Notes

Reaction equation

HRID 455249 reaction equation
C[O:2][C:3]([CH:5]1[CH2:10][CH:9]([C:11]([O:13]C)=[O:12])[CH2:8][N:7]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:6]1)=[O:4].C([O-])([O-])=O.[K+].[K+]>CO.O>[C:18]([O:17][C:15]([N:7]1[CH2:6][CH:5]([C:3]([OH:4])=[O:2])[CH2:10][CH:9]([C:11]([OH:13])=[O:12])[CH2:8]1)=[O:16])([CH3:21])([CH3:19])[CH3:20]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 497610141-Tert-butyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate

Product 1

HCID 232911311-(Tert-butoxycarbonyl)piperidine-3,5-dicarboxylic acid

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

To a solution of piperidine-1,3,5-tricarboxylic acid 1-tert-butyl ester 3,5-dimethyl ester (6.8 g, 22.5 mmol) in MeOH/water (4:1, 120 mL) is added K2CO3 (9.4 g, 68 mmol).

Sources & evidence

ORD record
ord-fc3147cd07f54baf9fda49483221cbcc
Source dataset
uspto-grants-2013_07
Patent number
US08497286B2

Reaction notes

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