反应详情

A mixture of 4-cyano-N-methylbutane-1-sulfonamide (Example 9; 100 mmol), acetic acid (100 ml) and concentrated hydrochloric acid (100 ml) was refluxed for 5 hours and then concentrated in vacuo. The residue was taken on THF and then filtered off. The filtrate was concentrated and the residue was washed with dichloromethane to give the pure product (11 g; 58% yield).

1. temperaturewas refluxed for 5 hours
2. concentrationconcentrated in vacuo
3. filtrationfiltered off
4. concentrationThe filtrate was concentrated
5. washthe residue was washed with dichloromethane
6. customto give the pure product (11 g; 58% yield)