反应详情

To a solution of 8-(benzyloxy)-5-(5-(tert-butoxycarbonylamino)-N-methylpentylsulfonamido)-1,6-naphthyridine-7-carboxylic acid (Example 2.4; 3.82 mmol) in dichloro methane (38 ml) were added HBTU (4.58 mmol) and DIPEA (15.8 mmol). The mixture was stirred for 5 min at rt. Ethyl 2-(aminomethyl)-5-fluorobenzoate hydrochloride (Example 4; 4.58 mmol) was added portionwise at rt. The mixture was stirred overnight at rt. The product was extracted with CH2Cl2, dried over MgSO4 and concentrated. The crude product was purified by SiO2 column chromatography (AcOEt:Hex, 1:1) to afford the target compound in 71% yield.

1. stirringThe mixture was stirred overnight at rt
2. extractionThe product was extracted with CH2Cl2
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customThe crude product was purified by SiO2 column chromatography (AcOEt:Hex, 1:1)
6. customto afford the target compound in 71% yield