反应详情

温度

100 °C

Propargylamine (0.21 mL) is added to a microwave oven suited vessel charged with a stir bar, 1-methyl-2-tetralone (0.50 mL), NaAuCl4*2H2O (27 mg), and ethanol (3 mL) (caution: a very exothermic reaction may evolve afterwards→keep an ice bath at hand). The resulting mixture is stirred under microwave irradiation at 100° C. for 10 min. After cooling the mixture to room temperature, the solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 25:75→0:100) to afford the title compound as an oil. Yield: 0.29 g (50% of theory); LC (method 1): tR=1.78 min; Mass spectrum (ESI+): m/z=198 [M+H]+.

1. additioncharged with a stir bar
2. custommay evolve afterwards→keep an ice bath at hand
3. temperatureAfter cooling the mixture to room temperature
4. customthe solvent is evaporated
5. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 25:75→0:100)