HRID4555

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11791542

2-({4-[2-(Cyclopropylmethoxy)ethyl]phenoxy}methyl)oxirane

C15H20O3

HCID13754334

未命名化合物

PRODUCTS

生成物

结构：NC(=O)c1cc(OCCN(Cc2ccccc2)CC(O)COc2ccc(CCOCC3CC3)cc2)ccc1O

HCID20151321

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A solution of 14.3 g of 1-[2-(cyclopropyl-methoxy)ethyl]-4-(2,3-epoxypropoxy)-benzene (German Offenlegungsschrift No. 2,649,605) and 16.3 g of 5-[2-(benzylamino)propoxy]-salicylamide in 200 ml of isopropanol is refluxed for 18 hours. The reaction mixture is concentrated by evaporation to leave crude 1-[N-[2-(3-carbamoyl-4-hydroxy-phenoxy)-ethyl]-benzylamino]-3-[4-[2-(cyclopropylmethoxy)ethyl]-phenoxy]-2-propanol in the form of brown oil, which can be further processed without additional purification.

WORKUP

后处理

concentrationThe reaction mixture is concentrated by evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b95195d2cd784a148d1234c8bc6ee701
来源数据集: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04727067
来源说明: uspto-grants-1988_02

反应 SMILES

[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH:16]3[O:18][CH2:17]3)=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[CH2:19]([NH:26][CH:27](C)[CH2:28][O:29][C:30]1[CH:38]=[C:34]([C:35]([NH2:37])=[O:36])[C:33]([OH:39])=[CH:32][CH:31]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(O)(C)C>[C:35]([C:34]1[CH:38]=[C:30]([CH:31]=[CH:32][C:33]=1[OH:39])[O:29][CH2:28][CH2:27][N:26]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:17][CH:16]([OH:18])[CH2:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][CH2:6][O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)=[CH:13][CH:12]=1)(=[O:36])[NH2:37]