Hydrochloric Acid → 6-Fluoro-7-(pyrrol-1-yl)-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Reaction Steps

A mixture of 1.2 g of ethyl 6-fluoro-7-(pyrrol-1-yl)-1-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate, 10 ml of ethanol, 15 ml of 10% sodium hydroxide solution and 10 ml of water is heated under reflux for 2 hours. 30 ml of 8M hydrochloric acid are added, the mixture is left to cool and the product is filtered off, washed with water and recrystallized from acetic acid to give 0.75 g of a solid melting at 284°-285° C.

Provenance & Evidence