反应详情

A mixture of 1.2 g of ethyl 6-fluoro-7-(pyrrol-1-yl)-1-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate, 10 ml of ethanol, 15 ml of 10% sodium hydroxide solution and 10 ml of water is heated under reflux for 2 hours. 30 ml of 8M hydrochloric acid are added, the mixture is left to cool and the product is filtered off, washed with water and recrystallized from acetic acid to give 0.75 g of a solid melting at 284°-285° C.

1. temperatureis heated
2. temperatureunder reflux for 2 hours
3. waitthe mixture is left
4. temperatureto cool
5. filtrationthe product is filtered off
6. washwashed with water
7. customrecrystallized from acetic acid