Hydrochloric Acid → HCID 178440328, compound

HRID 455915Notes

Reaction equation

HRID 455915 reaction equation
[CH3:1][CH2:2][CH2:3][C:4]1[C:5]2[N:14]=[C:13]([C:15]3[CH:16]=[C:17]([S:24]([N:27]4[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]4)(=[O:26])=[O:25])[CH:18]=[CH:19][C:20]=3[O:21][CH2:22][CH3:23])[NH:12][C:10](=[O:11])[C:6]=2[N:7]([CH3:9])[N:8]=1.C(C(O)(C(O)=O)CC(O)=O)C(O)=O.CO.[ClH:49]>C(O)C>[CH3:1][CH2:2][CH2:3][C:4]1[C:5]2[NH:14][C:13]([C:15]3[CH:16]=[C:17]([S:24]([N:27]4[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]4)(=[O:25])=[O:26])[CH:18]=[CH:19][C:20]=3[O:21][CH2:22][CH3:23])=[N:12][C:10](=[O:11])[C:6]=2[N:7]([CH3:9])[N:8]=1.[ClH:49]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 135413523Sildenafil Citrate

Product 1

HCID 178440328HCID 178440328, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sildenafil citrate (9.5 g) is dissolved in a mixture of ethanol (10 mL) and HCl (1N, 60 mL), then reacted at 50° C. for 10 mins. Under room temperature, the methanol is added for incubating over night and crystallization. Then, the crystal is filtrated to obtain precipitate of Sildenafil HCl (6.4 g) for use.

Workup

  1. customreacted at 50° C. for 10 mins
  2. waitfor incubating over night
  3. customcrystallization
  4. filtrationThen, the crystal is filtrated

Sources & evidence

ORD record
ord-622e3e675a384c18b597715b8e805b30
Source dataset
uspto-grants-2013_07
Patent number
US08497370B2

Reaction notes

Loading…